DHEA

DHEA (Dehydroepiandrosterone) is a hormone produced by the adrenal glands that serves as a precursor to male and female sex hormones. It is believed to support hormone balance, improve mood, and enhance energy levels, which can be beneficial for longevity and health optimization, especially as natural levels decline with age.

Intelligence Profile

Research Papers

Research Papers and Clinical Trials

Recent research on DHEA (dehydroepiandrosterone) spans several reproductive health conditions, though the evidence base remains limited with mixed findings.

Clinical Trial Evidence

The most robust clinical evidence comes from completed Phase 3 trials examining prasterone (a synthetic form of DHEA) as vaginal inserts for postmenopausal women. One completed study (NCT04982692) investigated INTRAROSA® vaginal inserts for vulvovaginal atrophy, while another Phase 3 trial is planned for women with breast cancer history experiencing genitourinary syndrome of menopause (NCT06611514).

For fertility applications, a completed Phase 3 trial (NCT02150330) examined DHEA supplementation effects on gene expression in cumulus cells during controlled ovarian hyperstimulation in women with diminished ovarian reserve. However, another early-phase study (NCT01129830) investigating DHEA's effects on ovarian reserve markers was terminated, indicating potential challenges in this research area.

Observational Research

An epidemiological study (NCT00005246) examined the relationship between DHEA sulfate levels and coronary heart disease mortality, highlighting DHEA's broader health implications beyond reproductive function.

Related Research Context

While not directly testing DHEA, recent 2026 publications provide relevant context for conditions where DHEA supplementation is sometimes considered. Studies have examined cellular mechanisms in polycystic ovary syndrome (PCOS), including granulosa cell dysfunction and autophagy pathways. Additional research has investigated how caloric restriction and time-restricted eating affect reproductive hormones in women.

Evidence Limitations

The clinical trial evidence for DHEA is notably sparse, with one fertility-related study terminated and limited completed trials focusing primarily on topical vaginal applications rather than systemic supplementation. Most recent research papers address related reproductive conditions but do not directly evaluate DHEA interventions.

Disclaimer: This information is for educational purposes only and should not replace consultation with healthcare providers for individual medical decisions.