Intelligence Profile
Clinical Applications
DHEA (dehydroepiandrosterone) is primarily investigated for reproductive and hormonal conditions, with most clinical research focusing on specific populations and indications.
Reproductive Health Applications
Diminished Ovarian Reserve
Clinical trials have examined DHEA supplementation in women with diminished ovarian reserve, a condition affecting fertility. One Phase 3 study investigated how DHEA affects gene expression in cumulus cells during controlled ovarian hyperstimulation in this patient population, though detailed results are not provided in the available evidence. Another early-phase trial examining DHEA's effects on ovarian reserve markers was terminated, limiting conclusions about efficacy in this indication.
Postmenopausal Conditions
DHEA in the form of prasterone (intravaginal DHEA) has been studied for postmenopausal vulvovaginal atrophy and genitourinary syndrome of menopause (GSM). A completed Phase 3 trial evaluated intravaginal prasterone for vulvovaginal atrophy, and another Phase 3 study is planned to examine its effects on GSM symptoms specifically in postmenopausal women with a history of breast cancer. These applications focus on local hormonal effects rather than systemic supplementation.
Cardiovascular Research
Limited evidence exists for DHEA's role in cardiovascular health. One epidemiological study examined the relationship between DHEA sulfate levels and coronary heart disease mortality, though this was observational rather than interventional research.
Evidence Limitations
The available clinical trial evidence for DHEA is limited, with several studies either terminated or lacking detailed outcome data. While the compound has been investigated across reproductive health applications, the evidence base appears incomplete for drawing definitive conclusions about clinical efficacy in most indications.
This information is for educational purposes only and should not replace professional medical advice. Consult with a healthcare provider before considering DHEA supplementation.