Ashwagandha
compound
Adaptogenic herb for stress and cortisol support. Supplement.
Updated 7/14/2026
DHEA
compound
DHEA (Dehydroepiandrosterone) is a hormone produced by the adrenal glands that serves as a precursor to male and female sex hormones. It is believed to support hormone balance, improve mood, and enhance energy levels, which can be beneficial for longevity and health optimization, especially as natural levels decline with age.
Updated 7/14/2026
Diosgenin
compound
Diosgenin is a naturally occurring steroidal saponin found in various plants, notably wild yam. It is a precursor for the synthesis of several hormones, including progesterone and other corticosteroids. Diosgenin is studied for its potential role in hormone balance and its anti-inflammatory properties, which may contribute to longevity and health optimization.
Updated 8/5/2026
Estradiol
compound
Estradiol is a form of estrogen, a key hormone in the regulation of the female reproductive system and secondary sexual characteristics. It plays a crucial role in bone density, cardiovascular health, and cognitive function, making it significant for longevity and health optimization, particularly in postmenopausal women.
Updated 7/14/2026
Estradiol 0.01% Vaginal Cream
compound
Estradiol 0.01% vaginal cream is a topical hormone therapy used primarily to alleviate symptoms of vaginal atrophy in postmenopausal women. It works by delivering a small dose of estradiol directly to the vaginal tissues, helping to restore moisture and elasticity. This is important for longevity and health optimization as it can improve quality of life and reduce discomfort associated with menopause.
Updated 8/5/2026
Estradiol Cypionate
compound
Depo-Estradiol. Long-acting estradiol ester. Injectable HRT option with ~2-week activity.
Updated 7/14/2026
Estrogen
compound
Estrogen is a primary female sex hormone crucial for reproductive and sexual development. It plays a significant role in bone density, cardiovascular health, and cognitive function. Estrogen therapy is often used in hormone replacement therapy to alleviate menopausal symptoms and may contribute to longevity by maintaining bone health and reducing cardiovascular risks.
Updated 8/11/2026
Exemestane
compound
Exemestane is an aromatase inhibitor primarily used to reduce estrogen levels by blocking the aromatase enzyme, which converts androgens into estrogens. This mechanism is particularly relevant in hormone-sensitive breast cancer treatment and may have implications for longevity by modulating hormone levels and reducing estrogen-driven cellular proliferation.
Updated 8/11/2026
Fezolinetant
compound
Fezolinetant is a neurokinin 3 (NK3) receptor antagonist primarily investigated for its role in managing menopausal symptoms, particularly hot flashes. By modulating the neurokinin B pathway, it helps regulate temperature control and hormonal balance, which can improve quality of life during menopause and potentially impact longevity by optimizing hormonal health.
Updated 8/5/2026
HCG
compound
LH analog maintains testicular function
Updated 7/14/2026
HGH (Somatropin)
compound
HGH (Somatropin) is a synthetic form of human growth hormone used to stimulate growth, cell reproduction, and regeneration. It plays a crucial role in maintaining tissue and organ health, and its decline with age is associated with decreased vitality. While it has potential benefits for longevity and health optimization, its use is controversial due to potential side effects and ethical concerns.
Updated 7/14/2026
HRT (Female Hormone Replacement Therapy)
compound
Hormone therapy. Bioidentical HRT using estradiol, progesterone, and sometimes testosterone. Restores estrogen, progesterone, and/or testosterone; reduces menopausal symptoms; protects bone and cardiovascular health.
Updated 7/14/2026
Human Growth Hormone (HGH/Somatropin)
compound
Norditropin, Humatrope, Genotropin. 191-amino acid recombinant human growth hormone. FDA-approved for GH deficiency, Turner syndrome, and HIV lipodystrophy. Used off-label for anti-aging and body composition.
Updated 7/14/2026
IGF-1 (Mecasermin)
compound
Increlex. Recombinant human IGF-1. FDA-approved for IGF-1 deficiency in children. Anti-aging and anabolic off-label use.
Updated 7/14/2026
Letrozole
compound
Letrozole is an aromatase inhibitor primarily used to treat hormone receptor-positive breast cancer by reducing estrogen production. It is also used off-label for fertility treatments and may have implications in hormone optimization for longevity by modulating estrogen levels.
Updated 8/5/2026
Maca
compound
Peruvian root for libido and energy support. Supplement.
Updated 7/14/2026
Menopausal Hormone Therapy
compound
Menopausal Hormone Therapy (MHT) involves the administration of hormones, typically estrogen and progesterone, to alleviate symptoms associated with menopause and to address long-term biological changes such as bone density loss. It is significant for longevity and health optimization as it can improve quality of life and reduce the risk of osteoporosis and cardiovascular issues in postmenopausal women.
Updated 8/5/2026
MK-677
compound
MK-677, also known as Ibutamoren, is a growth hormone secretagogue that stimulates the release of growth hormone and insulin-like growth factor 1 (IGF-1). It is primarily used to enhance muscle growth, bone density, and overall body composition, which are important for longevity and health optimization. Its ability to increase growth hormone levels without affecting cortisol levels makes it a promising compound for anti-aging purposes.
Updated 7/14/2026
Oxandrolone
compound
Anavar. Mild anabolic steroid with high anabolic:androgenic ratio. FDA-approved for muscle wasting conditions. Used for body composition and TRT augmentation.
Updated 7/14/2026
Oxytocin
compound
Bonding hormone enhances connection and orgasm
Updated 7/14/2026
Pregnenolone
compound
Pregnenolone is a precursor steroid hormone involved in the synthesis of various other hormones, including progesterone, estrogen, and testosterone. It plays a role in cognitive function, mood regulation, and stress response, making it relevant for longevity and health optimization. Its potential benefits include improved cognitive performance and mood stabilization.
Updated 7/14/2026
Progesterone (Bioidentical)
compound
Prometrium, Crinone. Bioidentical form of endogenous progesterone. FDA-approved oral micronized Prometrium. Used in HRT for women, hormone balance, and sleep improvement.
Updated 7/14/2026
Rhodiola
compound
Adaptogenic herb for stress and energy support. Supplement.
Updated 7/14/2026
Shilajit
compound
Mineral-rich substance for energy and vitality support. Supplement.
Updated 7/14/2026