Outcomes

The available evidence on DHEA outcomes is limited and primarily focused on specific reproductive health applications. Based on the clinical trials data, the following measurable results have been reported:

Reproductive Health Outcomes

Diminished Ovarian Reserve: One completed Phase 3 trial (NCT02150330) examined DHEA supplementation effects on cumulus cell gene expression in women with diminished ovarian reserve undergoing controlled ovarian hyperstimulation. However, specific outcome measures and results are not detailed in the available trial registry information.

A separate early-phase trial (NCT01129830) investigating DHEA's effect on ovarian reserve markers in women with diminished ovarian reserve was terminated, limiting available outcome data from this study.

Postmenopausal Vulvovaginal Atrophy: A completed Phase 3 trial (NCT04982692) evaluated intravaginal prasterone (DHEA) for postmenopausal vulvovaginal atrophy, though specific outcome measurements are not provided in the registry data.

Cardiovascular Outcomes

One epidemiological study (NCT00005246) examined the relationship between DHEA sulfate levels and coronary heart disease mortality, but measurable outcomes from this observational research are not detailed in the available information.

Evidence Limitations

The strength of evidence for DHEA outcomes is notably weak based on the available data. While several clinical trials have been completed, the specific measurable results—such as biomarker changes, symptom improvement scores, or clinical endpoints—are not reported in the trial registry information provided. Additionally, one relevant trial was terminated, further limiting the evidence base.

The PubMed literature provided does not contain studies directly evaluating DHEA outcomes, instead focusing on related hormonal and reproductive mechanisms that may be tangentially relevant but do not provide direct evidence of DHEA therapeutic effects.

Note: This summary is based on limited clinical trial registry information. Consult healthcare providers for personalized medical advice regarding DHEA supplementation.

DHEA

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