Magnesium Threonate

Research Papers and Clinical Trials

The available research on magnesium threonate is limited, with only a small number of studies directly investigating this compound.

Preclinical Research

Two animal studies provide the primary evidence for magnesium threonate's potential effects:

A 2026 comparative preclinical study (PMID: 42084749) examined magnesium-L-threonate against magnesium-acetyl-taurate, focusing on bioavailability, synaptic plasticity, and cognitive functions. However, specific sample sizes and detailed methodology are not available from the current evidence.

Another 2026 study (PMID: 41985648) investigated magnesium-L-threonate in a cyclophosphamide-induced cystitis model, examining its effects on bladder overactivity through inflammatory modulation and barrier restoration mechanisms. Again, study design details are not provided in the available evidence.

Clinical Trials

Five clinical trials are registered to study magnesium threonate, though most lack detailed published results:

Completed Studies:

• Two Phase 2 trials examined "MMFS" (likely referring to a magnesium threonate formulation) in early Alzheimer's disease (NCT03531684) and compared different dosages in older adults (NCT03601169)
• One completed trial studied a supplement combination including magnesium threonate for stress and sleep (NCT06889584)

Ongoing/Planned Studies:

• A study examining magnesium L-threonate's effects on sleep, recovery, and athletic performance in collegiate athletes is active but not recruiting (NCT07015047)
• A UCLA study on magnesium formulation in athletes has not yet begun recruiting (NCT07640685)

Research Limitations

The current evidence base for magnesium threonate is notably thin. Most studies lack published results with detailed sample sizes, methodology, or outcome data. The majority of research appears to be in early stages, with limited peer-reviewed publications available. More robust clinical data is needed to establish the compound's efficacy and safety profile.

This information is for educational purposes only and should not be considered personalized medical advice. Consult with a healthcare provider before starting any new supplement regimen.