Astaxanthin

Research Papers and Clinical Trials

Based on recent research findings, astaxanthin has been investigated across several therapeutic areas through both laboratory studies and clinical trials.

Clinical Trial Evidence

Several completed clinical trials have examined astaxanthin supplementation, though detailed results are not provided in the available evidence. A completed Phase 2 trial (NCT06429059) incorporated astaxanthin as part of a personalized treatment platform, while other completed studies investigated astaxanthin's effects on supplementation outcomes (NCT06511960), liver disease and inflammation markers (NCT06247137), and the safety profile of astaxanthin derived from Phaffia Rhodozyma (NCT03807050). An ongoing study is examining Antarctic krill oil containing astaxanthin for mitigating bladder cancer treatment side effects.

Laboratory and Preclinical Research

Recent laboratory studies have explored astaxanthin in multiple therapeutic contexts:

Athletic Performance: A randomized controlled trial examined 28-day astaxanthin supplementation in taekwondo athletes, measuring effects on psychological fatigue and biochemical markers, though specific sample sizes and outcomes are not detailed in the available evidence.

Inflammatory Conditions: Research has investigated covalently crosslinked chitosan-astaxanthin nanoparticles as an oral delivery system for chronic colitis treatment, suggesting improved bioavailability and therapeutic efficacy.

Cellular and Molecular Studies: Laboratory research has examined astaxanthin's effects on muscle cell development, showing synergistic effects with naringin on fish satellite cell proliferation and differentiation through mTOR signaling pathways. Additional molecular studies have investigated astaxanthin's potential in cardiac therapeutics through molecular docking studies of Drp1 modulation.

Radiation Protection: Studies have explored astaxanthin-containing formulations for radiation-induced lung injury, with research on ROS-responsive delivery systems and antioxidant defense mechanisms in radiation-tolerant microorganisms.

Limitations

The available evidence provides limited details on study sample sizes, specific outcomes, or statistical significance for most studies. While multiple clinical trials are listed as completed, their results and methodological details are not available in the current evidence base, limiting the ability to assess the clinical efficacy and safety profile of astaxanthin supplementation.

This information is for educational purposes only and should not replace professional medical advice. Consult with a healthcare provider before starting any supplement regimen.