Fisetin

Current Evidence Limitations

The safety profile of fisetin is not well-established through rigorous human clinical trials. Most available evidence comes from preclinical animal studies and in vitro research, with limited human safety data from ongoing or completed clinical trials.

Clinical Trial Safety Experience

Available clinical trial data is limited:

• One COVID-19 trial in older adults (NCT04537299) was terminated, though termination reasons are not specified in the available evidence
• One ongoing trial examining frailty in older women (NCT03430037) is currently enrolling by invitation
• Several other trials investigating fisetin have been withdrawn or suspended

Known Side Effects

Evidence for specific side effects in humans is thin. The available research does not provide comprehensive safety profiles or systematic adverse event reporting from human studies.

Contraindications and Precautions

Based on limited available evidence, specific contraindications have not been well-established. However, given the lack of robust human safety data, caution is warranted in:

• Pregnancy and breastfeeding (no safety data available)
• Children (no pediatric safety studies identified)
• Individuals with liver disease (though one study showed potential hepatoprotective effects in mice, human data is lacking)

Drug Interactions

The available evidence does not provide information about potential drug interactions with fisetin. This represents a significant knowledge gap that requires further investigation.

Populations That Should Exercise Caution

Given the limited human safety data, the following populations should exercise particular caution:

• Individuals taking multiple medications (unknown interaction potential)
• Those with chronic medical conditions
• Patients scheduled for surgery (unknown effects on bleeding or anesthesia)

Evidence Quality Statement

The safety evidence for fisetin is notably thin, consisting primarily of preclinical studies with minimal human clinical data. Most research has focused on potential therapeutic effects rather than comprehensive safety evaluation. More rigorous human safety studies are needed to establish a complete safety profile.

Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Consult with a healthcare provider before using fisetin, especially if you have medical conditions or take other medications.