NAD+

Research Papers and Clinical Trials

The current research on NAD+ encompasses several interconnected areas, though many of the studies are still emerging or in early phases.

Preclinical Research

Recent research has focused heavily on NAD+'s role in neurodegenerative diseases and metabolic dysfunction. Studies published in 2026 have examined how NAD+ metabolism interacts with cellular energy networks in Alzheimer's disease, particularly through the sirtuin protein family that depends on NAD+ for function. One paper explored the connection between bioenergetic impairment and tau protein changes in Alzheimer's, while another investigated the broader sirtuin network linking NAD+ metabolism to mitochondrial function and metabolic balance.

Additional preclinical work has examined NAD+'s role in other conditions, including pulmonary fibrosis and cellular injury models. However, specific study designs, sample sizes, and detailed methodology are not available in the provided evidence for these papers.

Clinical Trials

The clinical trial landscape for NAD+ supplementation is still developing, with several studies in various phases:

Completed Studies:

• A Phase 1/2 trial (NCT03423342) investigated nicotinamide riboside, an NAD+ precursor, in patients with systolic heart failure. Results from this completed study are not detailed in the available evidence.
• A supplementation and exercise study (NCT04907110) has been completed, though specific outcomes are not provided.

Ongoing Research:

• The NADAPT Study (NCT06162013) is currently recruiting participants for a randomized, double-blind Phase 2 trial examining NAD+ replenishment therapy for atypical Parkinsonism.

Limitations: The evidence base remains limited, with most studies either very recent or still in progress. Sample sizes, specific methodologies, and detailed outcomes are not available in the provided evidence, making it difficult to draw definitive conclusions about NAD+'s therapeutic potential.

Note: This synthesis is based solely on the limited evidence provided and should not be used for medical decision-making. Consult healthcare professionals for personalized medical advice.