NR

Research Papers and Clinical Trials

The available evidence for NR (nicotinamide riboside) research is currently limited, with only a handful of completed and ongoing clinical trials identified.

Clinical Trials:

The most relevant completed study is the NEET Trial (NCT04112043), a Phase 1 investigation examining nicotinamide riboside as an enhancer of exercise therapy in hypertensive older adults. Another completed trial (NCT04907110) studied NR supplementation in combination with exercise, though specific design details are not available from the current evidence.

Currently recruiting is the NADAPT Study (NCT06162013), a randomized double-blind Phase 2 trial investigating NAD replenishment therapy for atypical parkinsonism. An upcoming study (NCT07284225) plans to examine the acute effects of nicotinamide riboside on sleep structure in healthy adults using polysomnography measurements, though recruitment has not yet begun.

Research Papers:

The provided PubMed search results do not contain studies directly investigating nicotinamide riboside. One paper mentions "NR/EUG blends" (PMID: 42444337) but appears to focus on material science applications involving natural rubber compounds rather than the NAD+ precursor supplement.

Limitations:

The current evidence base for NR supplementation appears sparse, with most clinical trials either still in progress or providing limited publicly available data. The lack of published research papers specifically examining nicotinamide riboside in the provided search results suggests that comprehensive clinical evidence may be limited at this time.

This synthesis is based solely on the evidence provided and should not be considered personalized medical advice. Consult healthcare providers for individual treatment decisions.