5-Amino-1MQ
compound
NNMT Inhibitor. Small molecule NNMT (nicotinamide N-methyltransferase) inhibitor. Blocks NNMT to elevate NAD+ and SAM, improve mitochondrial function, and reduce fat cell activity. Metabolic health, fat loss, NAD+ elevation.
Updated 5/19/2026
Acarbose
compound
T2D medication with longevity properties. ITP study showed 20% lifespan extension in male mice. Modulates gut microbiome, increases GLP-1, reduces glycemic variability. Brand names: Precose, Glucobay.
Updated 5/19/2026
BAM15
compound
Novel mitochondrial protonophore uncoupler. Reverses diet-induced obesity in mice without affecting food intake or lean mass. More potent and selective than DNP.
Updated 5/19/2026
Low-Dose Naltrexone (LDN)
compound
At low doses (1.5-4.5mg), intermittently blocks opioid receptors causing upregulation. Anti-inflammatory, immune modulating, neuroprotective. Off-label for autoimmune, fibromyalgia, cancer.
Updated 5/19/2026
Metformin
compound
This research monograph on Metformin provides a comprehensive overview of its structure, pharmacology, and clinical significance as a first-line therapy for type 2 diabetes, highlighting its mechanism of action, safety profile, and pleiotropic effects including potential anti-aging properties. It includes data from pivotal studies demonstrating Metformin's effectiveness in reducing diabetes risk and complications. The document further explores pharmacokinetics and ongoing research into its broader applications, including possible use in cancer treatment and geroprotection.
Updated 5/20/2026
Niagen (Nicotinamide Riboside)
compound
NAD+ precursor that converts to NMN then NAD+. Clinically shown to increase NAD+ levels by ~60% in humans. Reduces arterial stiffness, neuroprotective. Brand name: Tru Niagen.
Updated 5/19/2026
NMN
compound
Direct NAD+ precursor. Elevates cellular NAD+ more efficiently than NR in some studies. Activates sirtuins. Declines with age.
Updated 5/20/2026
NR
compound
NAD+ precursor that converts to NMN then NAD+. Clinically shown to increase NAD+ levels by ~60% in humans. Reduces arterial stiffness, neuroprotective. Brand name: Tru Niagen.
Updated 5/19/2026
Rapamycin (Sirolimus)
compound
Most potent known longevity drug. Inhibits mTORC1 to suppress cellular senescence. Consistently extends lifespan in animals. Used off-label in small longevity doses. Brand name: Rapamune.
Updated 5/20/2026
SLU-PP-332
compound
Orally bioavailable REV-ERB agonist. Regulates circadian rhythm, metabolic function, fat oxidation, and muscle endurance. Studied as exercise mimetic.
Updated 5/19/2026
Tesofensine
compound
Triple monoamine reuptake inhibitor (SNDRI). Originally developed for Parkinsons/Alzheimers. Significant appetite suppression and weight loss in trials (10.6% weight loss at 0.5mg/day).
Updated 5/19/2026