Intelligence Profile
Research Papers
Research Papers and Clinical Trials
Research on Tongkat Ali (Eurycoma longifolia) has expanded in recent years, with studies exploring various compounds and potential applications, though clinical evidence remains limited.
Phytochemical Research
Recent laboratory studies have identified several bioactive compounds in Tongkat Ali. Researchers isolated new quassinoid carboxylic acids called Eurycomanoic Acids A-C from the plant, adding to the known chemical profile. Another study identified fluorescent compounds from the roots, while research on canthin-6-one derivatives showed potential antiparasitic activity against certain parasites in laboratory testing.
Cellular and Animal Studies
Several studies examined Tongkat Ali's effects at the cellular level. One study found that eurycomanone, a compound from Tongkat Ali roots, affected dopamine regulation in human neuroblastoma cells through specific signaling pathways. Another investigation using fruit flies and roundworms suggested that polysaccharides from Tongkat Ali might have anti-aging effects, though this was only tested in these simple animal models.
Clinical Trial Evidence
The clinical evidence for Tongkat Ali remains very limited. Only two clinical trials were identified:
A completed trial investigating "Tongkat Ali Maca Plus" (NCT05347329) for efficacy and safety, though no study details, sample size, or results are available from this listing.
A study evaluating four supplements including Tongkat Ali for "improving readiness for intimacy" (NCT05862519), but the status and results are unknown.
Evidence Limitations
The current research is heavily weighted toward laboratory studies examining individual compounds rather than clinical applications in humans. The available clinical trial information lacks critical details such as study design, participant numbers, duration, and outcomes. Most research focuses on identifying chemical compounds and testing effects in cell cultures or simple animal models, which may not translate to human benefits.
This information is for educational purposes only and should not replace professional medical advice. Consult with a healthcare provider before using any supplements.