Maca

Based on the available evidence, research on maca (Lepidium meyenii) spans several areas, though clinical data remains limited.

Preclinical Research

Recent systematic reviews and meta-analyses have examined maca's effects on exercise recovery and muscle health. One 2026 meta-analysis specifically analyzed preclinical studies investigating maca's impact on blood biomarkers of muscle damage and protein degradation following exercise, though the specific findings and number of included studies are not detailed in the available abstracts.

Animal studies have explored maca's hormonal effects, including a 2026 study examining black maca nano-emulsion in New Zealand white rabbit bucks. This research investigated effects on growth parameters, testosterone levels, testicular blood flow, and antioxidant defenses, suggesting potential reproductive health applications.

Cancer research has also emerged, with 2026 laboratory studies examining maca extracts' effects on prostate cancer cell lines, including impacts on cellular signaling, programmed cell death, and fat metabolism pathways.

Clinical Trials

Clinical trial activity appears limited but includes some notable studies:

• A completed Phase 3 trial (NCT00568126) investigated maca root for treating antidepressant-induced sexual dysfunction in women
• An ongoing study (NCT05891327) is examining maca extract for male sexual dysfunction
• A completed trial (NCT05347329) evaluated a combination product containing tongkat ali and maca

Knowledge Gaps

The evidence base remains thin for most proposed maca applications. While preclinical studies suggest potential benefits for muscle recovery, hormonal health, and cellular processes, robust clinical trial data is sparse. Most available studies focus on basic mechanisms rather than clinical outcomes in humans.

Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Consult healthcare providers before using maca for any health condition.