Intelligence Profile
Research Papers
Key Research Papers and Clinical Trials
Recent research on hormone replacement therapy (HRT) encompasses several specialized applications and populations, though detailed study designs and sample sizes are not available from the provided evidence.
Surgical and Recovery Applications
A 2026 study published in Cureus examined the effects of preoperative HRT on postmenopausal women undergoing rotator cuff repair surgery, suggesting potential benefits for surgical outcomes in this population.
Fertility and Reproductive Health
Multiple studies have investigated HRT in fertility treatments. Research published in the International Journal of Women's Health (2026) examined low-dose estradiol effects on clinical pregnancy rates during frozen-thawed embryo transfer cycles. Additionally, a retrospective cohort study of 917 cycles, published in Frontiers in Endocrinology (2026), analyzed serum progesterone levels for "rescue" protocols in hormone replacement frozen embryo transfer procedures. A prospective clinical cohort study in Reproductive Biology and Endocrinology (2026) evaluated pharmacodynamic interactions between dydrogesterone, progesterone, and estradiol in combination-progestin HRT for frozen embryo transfer.
Special Populations
Research has focused on HRT in specific medical populations. A 2026 Cureus study used propensity-matched analysis to examine long-term cancer implications of HRT in women with hypogonadotropic hypogonadism. Studies have also investigated HRT effects in Turner syndrome patients (comparing transdermal versus oral delivery methods and bone density outcomes) and in cancer survivors, including research on bone mineral density in childhood cancer survivors with premature ovarian insufficiency and menstrual health following hematopoietic transplant.
Ongoing Clinical Trials
Several clinical trials are currently recruiting participants, including the MUSE Study (NCT06530459), a Phase 2/3 trial investigating menopausal arthralgia, and the ENDO-BRAIN study (NCT06606535) examining cognitive effects of aromatase inhibitors in breast cancer patients.
Note: This synthesis is based on limited evidence from titles and basic study information only. Detailed results, methodologies, and clinical implications are not available from the provided sources.