Peptides

Fat-Targeting Pro-Apoptotic Peptide. Targets blood vessels feeding adipose tissue, triggers apoptosis in adipose vasculature. Fat loss, targeted adipose reduction.

Adipotide is a peptide designed for treating obesity by targeting white adipose tissue through a dual-domain mechanism that induces endothelial cell apoptosis. Preclinical studies indicate its effectiveness in weight reduction and metabolic improvement, although dose-dependent nephrotoxicity raises safety concerns. Formulation strategies are being explored to enhance its therapeutic potential while minimizing off-target effects.

Synthetically produced HGH fragment. Adds fat-targeted AOD-9604 to GH-optimization stack for simultaneous GH increase and fat mobilization.

AOD-9604 is a synthetic peptide derived from the C-terminal region of human growth hormone, aimed at promoting lipolysis without the growth-promoting effects. Its primary application focuses on metabolic disorders and weight management, showing promise in enhancing fat oxidation and recovery in orthopedic and sports medicine. Despite favorable safety profiles, AOD-9604 remains unapproved for therapeutic use in major jurisdictions, necessitating further clinical trials to establish its efficacy.

ARA 290. 11-amino acid EPO/TSHR agonist peptide. Activates tissue-protective receptor (EPOR-βcR). Neuroprotection, neuropathic pain, regeneration.

ARA-290, a non-erythropoietic peptide, represents a significant advancement in neuroprotective therapies, particularly for small fiber neuropathy. Engineered to activate the innate repair receptor (IRR) pathway, it offers tissue protection without stimulating red blood cells. Phase II clinical trials have shown efficacy in improving metabolic control and neuropathic symptoms among diabetic patients and individuals with sarcoidosis. With a promising safety profile and ongoing research into various therapeutic applications, ARA-290 is poised to make a considerable impact in neuropathy treatment.

BAM-15 is a novel mitochondrial uncoupler designed for targeted metabolic interventions. It functions as a protonophore, fostering controlled mitochondrial uncoupling to enhance energy expenditure while minimizing toxicity. Preclinical studies reveal its potential applications in metabolic disorders and environmental pest control, particularly against invasive aquatic species. Safety evaluations indicate a favorable therapeutic window, although further toxicological assessments are necessary.

BAM-15 is a novel mitochondrial uncoupler designed for targeted metabolic interventions. It functions as a protonophore, fostering controlled mitochondrial uncoupling to enhance energy expenditure while minimizing toxicity. Preclinical studies reveal its potential applications in metabolic disorders and environmental pest control, particularly against invasive aquatic species. Safety evaluations indicate a favorable therapeutic window, although further toxicological assessments are necessary.

Body Protection Compound-157. 15-amino acid peptide with remarkable tissue repair, gut healing, and anti-inflammatory effects. Derived from human gastric juice. Promotes angiogenesis and tendon/ligament healing.

PT-141, Vyleesi. Cyclic heptapeptide melanocortin receptor agonist. FDA-approved for HSDD in women (Vyleesi). Activates MC3R and MC4R in CNS to increase sexual arousal.

Neurotrophic peptide complex. Porcine brain-derived peptide preparation containing neurotrophic factors. Neuroprotective, promotes neuroplasticity. Used for stroke recovery, TBI, cognitive enhancement.

Modified GRF 1-29 with DAC modification. GHRH analog - shorter half-life (~30 min), allows more natural pulsatile GH pattern. Combined with Ipamorelin for synergistic effects.

Mod GRF 1-29 with Drug Affinity Complex. Long-acting synthetic GHRH analog with Drug Affinity Complex modification. Creates high, sustained GH release. Half-life ~8 days. Used for sustained GH elevation.

Mod GRF 1-29, CJC No DAC. Short-acting GHRH analog without DAC modification. Creates a high, pulsatile GH release, more natural GH stimulation. Combined with Ipamorelin for synergistic effects.

Neuroprotective hexapeptide. Synaptogenic, hepatocyte growth factor receptor agonist. Cognitive enhancement, neurogenesis. 10 million times more potent than BDNF in synapse formation.

Delta Sleep-Inducing Peptide. Nonapeptide. Modulates GABA, sleep architecture, hormonal balance. Promotes delta (slow-wave) sleep, modulates hormonal rhythms.

Selective estrogen receptor modulator stimulates LH/FSH

Synthetic tetrapeptide bioregulator derived from pineal gland extract. Activates telomerase, extends telomeres, regulates melatonin production, antioxidant. Sequence: Ala-Glu-Asp-Gly.

FST315. 315-amino acid glycoprotein. Inhibits myostatin and activin A. Promotes muscle growth and fat reduction. Myostatin inhibitor, anabolic.

Myostatin inhibitor promotes muscle growth

D-Retro-Inverso-retro-inverso peptide. Blocks FOXO4-p53 interaction, induces apoptosis in senescent cells. Senolytic, clearance of "zombie cells".

Copper tripeptide. GHK-Cu or Copper Peptide. Naturally occurring copper-binding tripeptide with potent regenerative, anti-aging, and wound-healing properties. Promotes skin repair, collagen synthesis, hair growth.

Potent GHRH/ghrelin mimetic; also activates CD36 receptor for cardioprotection. GH release, muscle growth, GI-1 increase. Research peptide.

Potent synthetic hexapeptide GH-releasing peptide. Also studied for appetite stimulation and anti-metabolic properties. GH release, appetite stimulation, muscle building, growth agonist.

GnRH, LHRH. Binds GnRH receptors to stimulate LH and FSH release from pituitary. TRT support, fertility. Injectable form for hormone stimulation.

Examorelin. Potent GHRP/ghrelin mimetic; also activates CD36 receptor for cardioprotection. GH release, muscle growth, cardioprotective. Research peptide.

This monograph details humanin, a 24-amino acid peptide derived from mitochondria, outlining its discovery, structure, and significant pharmacological properties. It discusses humanin's protective role in cardiovascular and renal health, its mechanisms of action through various signaling pathways, and its potential as a biomarker for diseases such as acute kidney injury and breast cancer. Additionally, ongoing clinical trials investigating its utility in fertility and chronic kidney disease suggest promising implications for personalized medicine.

This monograph details humanin, a 24-amino acid peptide derived from mitochondria, outlining its discovery, structure, and significant pharmacological properties. It discusses humanin's protective role in cardiovascular and renal health, its mechanisms of action through various signaling pathways, and its potential as a biomarker for diseases such as acute kidney injury and breast cancer. Additionally, ongoing clinical trials investigating its utility in fertility and chronic kidney disease suggest promising implications for personalized medicine.

IGF-1 Long R3 variant. 83-amino acid analog of IGF-1. Long-acting insulin-like growth factor with higher potency. Muscle growth, anabolism, fat loss, recovery.

GH secretagogue. Selective GHRP mimetic with minimal appetite/cortisol effects. Clean GH release, body composition, anti-aging. Often combined with CJC-1295 or Sermorelin.

Kisspeptin-54. GnRH-stimulating peptide. 54-amino acid neuropeptide that acts as a master regulator of GnRH/LH/FSH axis. Studied for testosterone optimization and fertility.

Metastin. GnRH-stimulating peptide from pituitary. Activates beta 2 adrenergic receptors; stimulates LH and FSH release from pituitary. Used for hormone optimization and fertility support.

Alpha-MSH fragment. Anti-inflammatory tripeptide (Lys-Pro-Val). Inhibits NF-kB pathway, modulates cytokine activity, promotes epithelial healing. Gut health, anti-inflammatory.

Tight junction regulator reduces intestinal permeability

Human cathelicidin. 37-residue antimicrobial peptide. Antimicrobial, wound healing. Immune cells and barrier epithelial antimicrobial immunity.

Cyclic heptapeptide analog of α-MSH. Activates melanocortin receptors. Tanning, sexual function, appetite suppression. Research peptide.

MT-II. Cyclic heptapeptide analog of α-MSH. Activates melanocortin receptors. Tanning, sexual function (in both sexes), appetite suppression. Research peptide.

This research monograph on Metformin provides a comprehensive overview of its structure, pharmacology, and clinical significance as a first-line therapy for type 2 diabetes, highlighting its mechanism of action, safety profile, and pleiotropic effects including potential anti-aging properties. It includes data from pivotal studies demonstrating Metformin's effectiveness in reducing diabetes risk and complications. The document further explores pharmacokinetics and ongoing research into its broader applications, including possible use in cancer treatment and geroprotection.

Mitochondria-derived peptide encoded in the 12S rRNA region. Activates AMPK pathway, regulates metabolic homeostasis, enhances insulin sensitivity. Exercise mimetic, longevity, metabolic health.

Direct mitochondrial fuel molecule essential for energy production

Nicotinamide Adenine Dinucleotide. Essential coenzyme involved in energy metabolism, DNA repair, sirtuin activation. Cellular energy, mitochondrial health.

Anabolic steroid for joint and tissue support

Pegylated Mechano Growth Factor. Splice variant of IGF-1 that promotes muscle satellite cell activation. Muscle repair, satellite cell activation, hypertrophy.

Body Protection Compound-157. 15-amino acid synthetic peptide with remarkable tissue repair, gut healing, and anti-inflammatory effects. Derived from human gastric juice.

Cyclic heptapeptide melanocortin receptor agonist. FDA-approved for HSDD in women (Vyleesi). Activates MC3R and MC4R in CNS to increase sexual arousal.

Tyr-Lys-Pro-Arg-Pro-Gly-Pro. Anxiolytic, nootropic peptide. Enhances BDNF, reduces anxiety, mood/immunity. Russian-developed for anxiety/cognitive support.

This research monograph provides an in-depth analysis of semaglutide, a GLP-1 receptor agonist effective for type 2 diabetes management and weight loss. It discusses its pharmacological mechanisms, clinical applications, safety profile, and emerging evidence highlighting neuroprotective effects. Furthermore, it reviews preclinical and clinical data, pointing towards various ongoing trials and the compound's evolving role in metabolic medicine.

Synthetic ACTH 4-10 analog. Enhances BDNF, neuroprotective and nootropic peptide. Increases BDNF, memory, focus, stroke recovery. Russian-developed cognitive enhancer.

GRF 1-29, GHRH 1-29. First-generation GHRH analog. 29-amino acid fragment of GHRH. GH stimulant, anti-aging, body composition. Compounded/FDA-approved for diagnosis of GH deficiency in children.

MTP-131, Bendavia. Mitochondria-targeting tetrapeptide that binds cardiolipin on inner mitochondrial membrane. Restores electron transport chain efficiency. Cardioprotection, ATP synthesis.

Thymosin Beta-4 fragment. 43-amino acid peptide. Promotes actin regulation and cellular migration. Muscle recovery, wound healing, flexibility, hair regrowth. Promotes cellular migration and healing via actin binding.

Full Thymosin Beta-4. 43-amino acid and regenerative peptide discovered in thymus. Promotes actin regulation and cellular migration. Muscle recovery, wound healing, flexibility, hair regrowth.

TH9507, Egrifta. 44-amino acid GHRH analog. Modified GHRH analog stabilized with trans-3-hexenoic acid. FDA-approved GHRH analog for HIV lipodystrophy. Visceral fat reduction, GH release, body composition.

Immune modulator enhances T-cell function and regulatory immunity

Thymalfasin, Zadaxin. 28-amino acid peptide derived from thymic hormone thymosin fraction 5. Immune enhancement, antiviral, T-cell activation. FDA-approved in some countries.

Active 17-amino acid fragment of Thymosin Beta-4. Promotes wound healing, tissue repair, and anti-inflammatory effects. More affordable than full TB-4.