Vibegron

Vibegron is a medication used to manage symptoms of overactive bladder (OAB). It works as a selective beta-3 adrenergic receptor agonist. By activating these receptors located primarily in the bladder's detrusor muscle, vibegron promotes relaxation of the bladder muscle, leading to an increase in bladder capacity and a reduction in symptoms like urgency, frequency, and incontinence.

The mechanism involves stimulating beta-3 adrenergic receptors, which are part of the sympathetic nervous system. Activation of these receptors results in the relaxation of the detrusor muscle during the storage phase of the bladder filling cycle. This allows the bladder to hold more urine and reduces involuntary contractions that cause the symptoms of OAB.

Several clinical trials and reviews underscore its efficacy in patients resistant to anticholinergic therapies and its tolerability in various populations, including older adults and specific pediatric cases with neurogenic bladder conditions.

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This content is informational and not a substitute for professional medical advice. Always consult a healthcare provider for personalized care.