Intelligence Profile
Research Papers
Research on L-Citrulline includes varying focuses, from its pharmacokinetics to its potential therapeutic effects.
Pharmacokinetics Study: A study on neonatal Holstein calves (2026) evaluated the pharmacokinetics and short-term tolerability of both intravenous and oral L-Citrulline. This investigation helps in understanding how this compound is processed in the body, potentially informing dosing and delivery methods.
Oxidative Stress: Research published in Cellular Signalling (2026) highlighted L-Citrulline's potential in reducing oxidative stress-induced damage in nucleus pulposus cells by inhibiting inflammasome assembly. This suggests L-Citrulline could have a cellular protective role.
Clinical Trials:
- Sepsis: A clinical trial (NCT02370030) explored how Citrulline might impact biochemical progression in sepsis patients, although the current status is unknown.
- Small Bowel Toxicity: Another completed trial (NCT01849107) investigated plasma Citrulline as a biomarker for radiation-induced small bowel toxicity, suggesting its potential for monitoring radiation effects.
- Adolescents with MASLD: A completed trial (NCT05778266) examined the effects of L-Citrulline combined with high-intensity interval training on arterial stiffness, body composition, and lipid profile in adolescents with metabolic-associated steatosis.
This body of work illustrates a growing interest in understanding L-Citrulline's various roles and potential benefits in different medical and physiological contexts. However, more targeted research in humans is necessary to fully elucidate its therapeutic applications.
Disclaimer: This information is for educational purposes only and not intended as medical advice. Consult a healthcare professional for personalized guidance.