Berberine
compound
Berberine is a plant alkaloid known for its potential to improve metabolic health by activating AMP-activated protein kinase (AMPK), which plays a key role in regulating glucose and lipid metabolism. It is often used as a natural alternative to metformin for managing blood sugar levels and may support longevity by improving metabolic markers.
Updated 7/14/2026
GIP
compound
GIP, or Glucose-dependent Insulinotropic Polypeptide, is an incretin hormone that plays a role in glucose metabolism by stimulating insulin secretion in response to nutrient intake. It is being explored for its potential in managing metabolic disorders such as diabetes, which are critical for longevity and health optimization.
Updated 7/14/2026
GLP-1
compound
GLP-1, or glucagon-like peptide-1, is a hormone involved in the regulation of appetite and insulin secretion. It plays a crucial role in metabolic health by enhancing insulin sensitivity and promoting satiety, which can aid in weight management and reduce the risk of metabolic disorders. Its relevance to longevity and health optimization lies in its potential to improve metabolic parameters and reduce the risk of type 2 diabetes.
Updated 7/14/2026
Metformin
compound
Metformin is a widely used medication primarily for managing type 2 diabetes, known for its ability to improve insulin sensitivity and lower blood sugar levels. It is being studied for its potential longevity benefits, as it may influence pathways related to aging and metabolic health, such as AMPK activation. Its extensive research history makes it a compound of interest for health optimization and longevity.
Updated 7/14/2026
Peptide YY
compound
Peptide YY is a gut-derived hormone that plays a role in regulating appetite and energy balance. It is released postprandially and acts to reduce appetite by slowing gastric emptying and signaling satiety to the brain. Understanding and modulating Peptide YY levels could be significant for managing obesity and metabolic health, which are crucial for longevity.
Updated 7/14/2026
Spermidine
compound
Spermidine is a naturally occurring polyamine that plays a crucial role in cellular processes such as autophagy, which is the body's way of cleaning out damaged cells to regenerate newer, healthier cells. It is believed to contribute to longevity and health optimization by promoting cellular renewal and reducing oxidative stress.
Updated 7/14/2026