Berberine
compound
Berberine is a plant alkaloid known for its potential to improve metabolic health by activating AMP-activated protein kinase (AMPK), which plays a key role in regulating glucose and lipid metabolism. It is often used as a natural alternative to metformin for managing blood sugar levels and may support longevity by improving metabolic markers.
Updated 7/14/2026
GIP
compound
GIP, or Glucose-dependent Insulinotropic Polypeptide, is an incretin hormone that plays a role in glucose metabolism by stimulating insulin secretion in response to nutrient intake. It is being explored for its potential in managing metabolic disorders such as diabetes, which are critical for longevity and health optimization.
Updated 7/14/2026
GLP-1
compound
GLP-1, or glucagon-like peptide-1, is a hormone involved in the regulation of appetite and insulin secretion. It plays a crucial role in metabolic health by enhancing insulin sensitivity and promoting satiety, which can aid in weight management and reduce the risk of metabolic disorders. Its relevance to longevity and health optimization lies in its potential to improve metabolic parameters and reduce the risk of type 2 diabetes.
Updated 7/14/2026
Glucagon-Like Peptide-1 Agonist (GLP-1)
compound
Glucagon-Like Peptide-1 Agonists (GLP-1) are compounds that mimic the incretin hormone GLP-1, which enhances insulin secretion and inhibits glucagon release, thereby improving blood glucose control. They are primarily used in the management of type 2 diabetes and have shown potential in weight management and cardiovascular health, making them relevant for longevity and health optimization.
Updated 8/5/2026
Ketone-IQ
compound
Ketone-IQ is a ketone supplement designed to elevate blood ketone levels, providing an alternative energy source for the body and brain. This can enhance metabolic efficiency and support cognitive function, potentially benefiting longevity by mimicking some effects of caloric restriction and improving metabolic health.
Updated 8/11/2026
Metformin
compound
Metformin is a widely used medication primarily for managing type 2 diabetes, known for its ability to improve insulin sensitivity and lower blood sugar levels. It is being studied for its potential longevity benefits, as it may influence pathways related to aging and metabolic health, such as AMPK activation. Its extensive research history makes it a compound of interest for health optimization and longevity.
Updated 7/14/2026
Peptide YY
compound
Peptide YY is a gut-derived hormone that plays a role in regulating appetite and energy balance. It is released postprandially and acts to reduce appetite by slowing gastric emptying and signaling satiety to the brain. Understanding and modulating Peptide YY levels could be significant for managing obesity and metabolic health, which are crucial for longevity.
Updated 7/14/2026
SGLT2 Inhibitor
compound
SGLT2 inhibitors are a class of medications that lower blood sugar by preventing the kidneys from reabsorbing glucose, leading to its excretion in urine. They are primarily used to manage type 2 diabetes but have shown potential benefits for cardiovascular health and weight management, making them relevant for longevity and health optimization.
Updated 8/5/2026
Spermidine
compound
Spermidine is a naturally occurring polyamine that plays a crucial role in cellular processes such as autophagy, which is the body's way of cleaning out damaged cells to regenerate newer, healthier cells. It is believed to contribute to longevity and health optimization by promoting cellular renewal and reducing oxidative stress.
Updated 7/14/2026
Tralesinidase Alfa
compound
Tralesinidase alfa is an enzyme replacement therapy designed to treat metabolic disorders by supplementing deficient or malfunctioning enzymes. Its primary mechanism involves restoring normal metabolic function, which can help manage symptoms and improve quality of life in affected individuals. This compound is relevant for longevity and health optimization as it addresses underlying metabolic dysfunctions that can lead to chronic health issues.
Updated 8/11/2026