AADvac1
compound
AADvac1 is an investigational vaccine targeting tau proteins, which are implicated in neurodegenerative diseases like Alzheimer's. By inducing an immune response against pathological tau, it aims to prevent or slow the progression of cognitive decline. This approach is significant for longevity and health optimization as it addresses a major cause of age-related cognitive impairment.
Updated 8/5/2026
Aripiprazole
compound
Aripiprazole is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. It acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. Its relevance to longevity and health optimization is mainly through its potential cognitive-enhancing effects and mood stabilization, which can contribute to improved mental health and quality of life.
Updated 8/11/2026
Creatine
compound
Creatine is a compound that plays a critical role in energy production, particularly in muscle and brain tissues. It is widely used for its benefits in enhancing physical performance and cognitive function. For longevity and health optimization, creatine supports muscle health, cognitive resilience, and may have neuroprotective effects.
Updated 8/5/2026
Donanemab
compound
Donanemab is a monoclonal antibody designed to target and clear amyloid-beta plaques in the brain, which are associated with Alzheimer's disease. By reducing these plaques, it aims to slow cognitive decline and improve brain health, making it relevant for longevity and cognitive optimization.
Updated 8/5/2026
Droxidopa
compound
Droxidopa is a synthetic amino acid precursor that is converted to norepinephrine in the body. It is primarily used to treat neurogenic orthostatic hypotension, a condition that can cause dizziness and fainting due to low blood pressure. By increasing norepinephrine levels, droxidopa may also have potential benefits for cognitive enhancement and improving autonomic function, which are relevant for longevity and health optimization.
Updated 8/11/2026
Istradefylline
compound
Istradefylline is an adenosine A2A receptor antagonist primarily used as an adjunctive treatment for Parkinson's disease to improve motor function. By modulating adenosine pathways, it may offer cognitive benefits and neuroprotection, which are relevant for longevity and health optimization.
Updated 8/11/2026
Lithium Low-Dose
Low-dose lithium is a trace mineral that has been studied for its potential neuroprotective and mood-stabilizing effects. It is thought to enhance cognitive function and protect against neurodegenerative diseases by modulating neurotransmitter activity and reducing oxidative stress. Its relevance to longevity and health optimization lies in its potential to support brain health and cognitive longevity.
Updated 7/14/2026
Low-Dose Aripiprazole
compound
Aripiprazole, typically used as an antipsychotic, is being explored at low doses for potential cognitive enhancement and mood stabilization. Its mechanism involves partial agonism of dopamine D2 and serotonin 5-HT1A receptors, which may support cognitive function and emotional regulation. This could be relevant for longevity by potentially improving mental health and cognitive resilience.
Updated 8/5/2026
Lumateperone
compound
Lumateperone is an atypical antipsychotic primarily used for the treatment of schizophrenia. It works by modulating serotonin, dopamine, and glutamate pathways, which are crucial for cognitive function and mood regulation. Its relevance to longevity and health optimization lies in its potential to improve mental health and cognitive function, which are critical components of overall well-being.
Updated 8/5/2026
Methylene Blue
compound
Methylene Blue is a synthetic compound with potential cognitive-enhancing properties. It acts as an electron carrier in the mitochondrial electron transport chain, which may improve cellular energy production and protect against oxidative stress. This mechanism is particularly relevant for neuroprotection and cognitive health, making it a compound of interest for longevity and health optimization.
Updated 7/14/2026
Psilocybin
compound
Psilocybin is a naturally occurring psychedelic compound found in certain mushrooms. It primarily acts on serotonin receptors in the brain, leading to altered perception and cognition. Psilocybin is being studied for its potential to enhance cognitive function and mental health, which can contribute to overall longevity and health optimization.
Updated 8/5/2026
Selank
Selank is a synthetic peptide derived from the naturally occurring tetrapeptide tuftsin. It is primarily used for its anxiolytic and nootropic effects, potentially enhancing cognitive function and reducing anxiety. Selank's mechanism involves modulation of neurotransmitter systems, which may contribute to improved mental clarity and stress resilience, making it relevant for cognitive enhancement and mental health optimization.
Updated 7/14/2026
Semax
compound
Semax is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) that is primarily used for its nootropic and neuroprotective effects. It is believed to enhance cognitive function by modulating neurotransmitter systems and promoting neurogenesis. Although it shows promise for cognitive enhancement and neuroprotection, its impact on longevity and health optimization requires further investigation.
Updated 7/14/2026
Tau2
compound
Tau2 is a compound related to the modulation of tau proteins, which are associated with neurodegenerative diseases like Alzheimer's. Its primary mechanism involves influencing tau protein aggregation, which is crucial for maintaining neuronal health and function. This compound matters for longevity and health optimization as it targets cognitive decline, a significant concern in aging populations.
Updated 8/5/2026