Search & Documents API

{
  "query": "peptide healing gut barrier",
  "types": ["compounds", "documents", "research"],
  "filters": {
    "evidence_grade": ["A", "B"],
    "category": "peptide",
    "compound_type": ["therapeutic"]
  },
  "limit": 20,
  "offset": 0,
  "sort": "relevance",
  "include_research": true,
  "include_abstracts": true
}

{
  "success": true,
  "data": {
    "query": "peptide healing gut barrier",
    "results_total": 234,
    "results": [
      {
        "type": "compound",
        "id": "bpc-157",
        "name": "BPC-157",
        "slug": "bpc-157",
        "category": "peptide",
        "evidence_grade": "B",
        "relevance_score": 0.98,
        "summary": "Pentadecapeptide with potent regenerative properties for gut healing and barrier function restoration",
        "research_count": 45,
        "typical_dosage": "250-500mcg daily",
        "route_of_administration": ["subcutaneous", "oral"]
      },
      {
        "type": "document",
        "id": "doc-2024-0145",
        "title": "Efficacy of BPC-157 in Intestinal Permeability: A Systematic Review",
        "authors": ["Smith J.", "Johnson M.", "Williams R."],
        "publication_date": "2024-03-15",
        "journal": "Clinical Research Quarterly",
        "evidence_grade": "A",
        "relevance_score": 0.96,
        "abstract": "This systematic review examined 12 clinical and preclinical studies demonstrating BPC-157's effectiveness...",
        "doi": "10.1234/crq.2024.0145",
        "url": "https://journals.example.com/crq/2024/0145"
      },
      {
        "type": "research",
        "id": "res-peptide-gut-healing",
        "title": "Peptide-Based Therapies for Gut Barrier Dysfunction",
        "content_preview": "Peptides have emerged as promising therapeutic agents for restoring intestinal barrier integrity...",
        "topics": ["gut-barrier", "leaky-gut", "peptides", "healing"],
        "relevance_score": 0.94
      }
    ],
    "facets": {
      "types": [
        { "name": "compounds", "count": 12 },
        { "name": "documents", "count": 89 },
        { "name": "research", "count": 133 }
      ],
      "evidence_grades": [
        { "grade": "A", "count": 34 },
        { "grade": "B", "count": 89 },
        { "grade": "C", "count": 78 },
        { "grade": "D", "count": 26 },
        { "grade": "E", "count": 7 }
      ],
      "categories": [
        { "name": "peptide", "count": 67 },
        { "name": "supplement", "count": 45 },
        { "name": "medication", "count": 34 },
        { "name": "food", "count": 88 }
      ]
    },
    "pagination": {
      "limit": 20,
      "offset": 0,
      "total": 234,
      "pages": 12
    }
  }
}

GET https://api.axifi.ai/v1/monographs/bpc-157

{
  "success": true,
  "data": {
    "slug": "bpc-157",
    "name": "BPC-157",
    "full_name": "Body Protection Compound-157",
    "classification": {
      "type": "peptide",
      "category": "bioregulator",
      "subcategory": "healing"
    },
    "structure": {
      "molecular_formula": "C₆₂H₉₈N₁₆O₁₉",
      "molecular_weight": 1419.5,
      "sequence": "G E G D L A T G E N D P N P E G A E G E S D L A T G E N D P N P E G A E G E S D L A T G",
      "type": "pentadecapeptide"
    },
    "mechanism_of_action": [
      "Activates growth hormone-releasing peptide 6 (GHRP-6) receptors",
      "Enhances angiogenesis and tissue repair",
      "Reduces inflammation via IL-10 modulation",
      "Restores intestinal barrier integrity",
      "Promotes collagen synthesis"
    ],
    "clinical_evidence": {
      "evidence_grade": "B",
      "human_studies": 12,
      "preclinical_studies": 87,
      "clinical_outcomes": [
        "Accelerates wound healing",
        "Improves intestinal permeability",
        "Reduces inflammatory markers",
        "Enhances recovery from injury"
      ]
    },
    "indications": [
      {
        "condition": "Intestinal permeability (leaky gut)",
        "evidence_grade": "B",
        "typical_dosage": "250-500mcg daily",
        "duration": "4-12 weeks"
      },
      {
        "condition": "Wound and soft tissue healing",
        "evidence_grade": "B",
        "typical_dosage": "250mcg twice daily",
        "duration": "4-8 weeks"
      },
      {
        "condition": "Joint and cartilage repair",
        "evidence_grade": "C",
        "typical_dosage": "250-500mcg daily",
        "duration": "8-12 weeks"
      }
    ],
    "dosing": {
      "route": ["subcutaneous", "oral"],
      "typical_dose": "250-500mcg daily",
      "loading_dose": null,
      "frequency": "1-2 times daily",
      "duration": "4-12 weeks",
      "notes": "Best results typically observed after 4 weeks of consistent dosing"
    },
    "safety_profile": {
      "adverse_events": "Well-tolerated with minimal reported adverse events",
      "common_side_effects": [],
      "serious_side_effects": [],
      "contraindications": [
        "Pregnancy and breastfeeding",
        "Active malignancy"
      ],
      "fda_status": "Research compound - not FDA approved"
    },
    "interactions": {
      "drug_interactions": [],
      "supplement_interactions": [],
      "food_interactions": []
    },
    "cost_estimate": "$30-60 per month",
    "related_compounds": [
      "TB-500",
      "IGF-1",
      "GHRP-6"
    ],
    "research_papers": 45,
    "last_updated": "2024-05-05T10:30:00Z"
  }
}